Validation of the Analytical Method for In-Vivo Determination of Meloxicam and Bioequivalence Study from Meloxicam Containing Microparticle Formulations in Rabbits

Inflammation reaction is a rapid process induced by prostaglandin E2 (PGE2) which is one of the yield products of cyclooxygenase (COX) enzyme. Mechanical trauma, corrosive chemicals and antigen-antibody reactions are the most common stimulants of inflammation reaction in the body. PGE2 affects the neurons resulting in systemic inflammation symptoms such as edema, pain and fever 1-2. Three different types of COX enzymes exist in the human body, which are named as COX-1, COX-2 and COX-3. The COX-3 enzyme is a splice variant of COX-1 enzyme that retains intron one and has a frame shift mutation. Depending on this similarity it is sometimes named as COX-1b or COX-1 variant. COX1 and COX-2 types are expressed at different levels in human tissues. Although they are very much similar in fashion, selective inhibition is the discriminating factor in terms of side effects. COX-1 enzyme is generally Hacettepe University Journal of the Faculty of Pharmacy Volume 29 / Number 2 / July 2009 / pp. 115-130